KES
Search
- Page Path
- HOME > Search
Original Article
- Clinical Study
- Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
- Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
- Endocrinol Metab. 2018;33(3):364-371. Published online September 18, 2018
- DOI: https://doi.org/10.3803/EnM.2018.33.3.364
- 3,533 View
- 50 Download
- 7 Web of Science
- 6 Crossref
-
Abstract
PDF
PubReader 
ePub Background Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.
Methods Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.
Results Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.
Conclusion Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.
-
Citations
Citations to this article as recorded by
- Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study
Asif Jan, Zakiullah, Sajid Ali, Basir Muhammad, Amina Arshad, Yasar Shah, Haji Bahadur, Hamayun Khan, Fazli Khuda, Rani Akbar, Kiran Ijaz, Giuseppe Novelli
PLOS ONE.2023; 18(1): e0281070. CrossRef - Silencing LncRNA PVT1 Reverses High Glucose-Induced Regulation of the
High Expression of PVT1 in HRMECs by Targeting miR-128-3p
Xuyang Wang, Wangling Chen, Wei Lao, Yunxin Chen
Hormone and Metabolic Research.2022; 54(02): 119. CrossRef - Association of CAPN10 (SNP-19) genetic polymorphism and obesity with T2DM: a study on Bengali Hindu caste population
Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay
International Journal of Diabetes in Developing Countries.2021; 41(1): 37. CrossRef - Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study
Ariunbold Chuluun-Erdene, Orgil Sengeragchaa, Tsend-Ayush Altangerel, Purevjal Sanjmyatav, Batnaran Dagdan, Solongo Battulga, Lundiamaa Enkhbat, Nyamjav Byambasuren, Munkhzol Malchinkhuu, Munkhtstetseg Janlav
Medical Sciences.2020; 8(3): 38. CrossRef - Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
PLOS ONE.2020; 15(10): e0241078. CrossRef - Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
Molecular Biology Reports.2019; 46(1): 325. CrossRef
- Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study
First
Prev
